From Star Trek: Theurgy Wiki
The USS Enterprise (NCC-1701) was a Federation Constitution-class starship in service to Starfleet during the 23rd century. The vessel was commanded by seven captains, including Robert April, Christopher Pike, and the most famous of them all, James T. Kirk. When construction began on the Enterprise in 2242, the ship was designated NX-0002.
The Enterprise remained in service for forty years, engaging in numerous first contacts, military engagements, and time travel missions. She eventually gained everlasting fame during her five-year mission, under the command of Captain Kirk. Enterprise underwent a massive refit in 2270, engaged V'Ger in 2273, and self-destructed over the Genesis Planet in 2285. The Enterprise would go on to become one of the most famous Federation starships in history; so famous in fact that when Earth and Starfleet had been saved by Kirk and his crew in 2286, the Federation Council and President decided to thank them by recommissioning another Constitution-class starship, the USS Enterprise-A, and assigning them to it. The Enterprise would also be known as the Federation flagship through her service life.
Over the years, the Enterprise crew represented a wide diversity of races and cultures, including some non-humanoids and a variety of humanoid species, including Humans, Vulcans, Andorians, Tellarites, Lirin, Caitians, Betelgeusians, Kelyans, Zaranites, Saurians, Argelians, Rhaandarites, Sulamids, Triexians, Gallamites, Deltans, Tanians and even representatives of reclusive non-aligned cultures, such as a Klingon, Gorn and a Horta.